When it comes to the effects of cannabis, women and men are worlds apart. Although scientific research about how cannabis affects and interacts with our bodies, few of those clinical or preclinical studies don’t analyze separately reactions of both male and female subjects. And trust us, there is a whole universe to discover in how cannabis affects men and women differently.

Spoiler alert: as you will see throughout this post, one of the ways that cannabis affects men and women differently is appetite. Apparently, and according to research, girls don’t get such a bad munchies as men. But before we get into studies, scientists and tests, let’s talk about sex. Oh, yeah.

Cannabis and sexual experience in women

Cannabis and sexual experience in women

It is not a secret that many women tend to feel discomfort or even pain during sexual relationships. According to a study published in The Journal of Sexual Medicine, “women, regardless of sexual orientation, have less predictable, more varied orgasm experiences than men”. This is why companies are starting to develop products to enhance and improve sexual experience in women.

Foria is a company that develops suppositories for PMS, also produces a “weed lube” to precisely enhance women’s sexual pleasure. This product, as said on their website, “can increase arousal, promote natural lubrication, and heighten tactile sensation — making orgasms fuller, more intense, or easier to access”.

The endocannabinoid system also plays a major role in sex. Sex therapist Lawrence Siegel said on CNN that THC appears to target a brain area associated with sex arousal in females. “Our body’s natural endocannabinoid system is key in regulating things like pleasure, pain, relaxation and homeostasis. When it is activated by the cannabinoids in cannabis, it can leave users feeling relaxed with increased pleasure and decreased pain”.

Women experience cannabis differently because of estrogen, the sex hormone. Although it appears that cannabinoids such as THC and CBD work a whole lot better in women, but there is still a catch.

Cannabis and the sex hormone estrogen

To answer the question on why cannabis affects men and women differently, we have to talk about estrogen. Although all sex hormones, such as testosterone and progesterone, have an impact in how the body processes cannabinoids, the most important sex hormone in this particular subject we are discussing is estrogen. But why estrogen? Because estrogen is the sex hormone that interacts directly with the endocannabinoid system. Even more, estrogen determines the strength of cannabinoids effect in our bodies.

Although men also have estrogen in their bodies, women’s level of the hormone are much higher. Estrogen plays an important role in women’s sexual development. Also, along with another sex hormone called progesterone, it regulates women’s menstrual cycle, affecting the reproductive system.

Estrogen has a strong relation with the endocannabinoid system. In some brain regions, the amount of CB1 receptors varies with the amount of estrogen in the brain. Additionally, a study found that estrogen increases anandamide levels. Therefore, estrogen also strengthens the endocannabinoid system. Furthermore, another research found out that when estrogen levels are high in rats, this rodents get higher!  Researchers found that rats with high estrogen levels experienced a stronger effect of THC. This findings suggest a relationship between CB1 receptor, THC, estrogen and the endocannabinoid system.

THC and estrogen are not such a good match

As we explained above, there is a strong relationship between the endocannabinoid system, cannabinoids and estrogen. But this relationship is not a good one, it appears. When THC and estrogen interact between each other, CB1 receptors get highly activated. Consequently, the endocannabinoid system get unbalanced. This unbalanced ECS can result in alterations in mood and anxiety because of a change in size in the tonsils, a nervous tissue located in the temporal lobe. Adolescent women who are regular cannabis consumers have larger tonsils than male cannabis users, study finds.

This could mean than women who are regular cannabis user are more vulnerable to suffer anxiety in adolescence, as researchers conclude:

“Gender interactions may reflect marijuana-related interruptions to sex-specific neuromaturational processes and staging. Subtle amygdala development abnormalities may underlie particular vulnerabilities to sub-diagnostic depression and anxiety in teenage female marijuana users”.

Studies on how cannabis affects men and women differently

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A 2011 study analyzed the effects of marijuana on driving performance. A total of 85 people participated in the study: 50 men and 35 women. Before getting to the driving simulator, researchers divided the group in two. One group received a placebo (0% of THC) while the other one got a 2.9% THC dose of marijuana. Interestingly, eight females and only one male decided not to complete the marijuana cigarette. And after consuming the cannabis (or placebo) cigarette, subjects were told to go to perform the test. To the driving simulator!

The first result that was different between male and female was in “highness”. Scientists observed that women actually rated themselves to feel “higher” than men, both in active THC dose and with the placebo. Also, women felt more sleepy than men after completing the driving test. And, just to point the main result of the test, it is not recommended to drive under the influence of high THC cannabis strains: “This study supports the existing literature that marijuana does affect simulated driving performance, particularly on complex tasks such as divided attention”.

Another research found that after giving a sublingual dose of THC, women and men had very different effects in spatial working memory performance. While men showed no changes at all, THC actually enhanced spatial working memory.

Another study analyzed the differences between male and female in terms of cannabinoid-regulated biology. The research focused especially in homeostasis. And remember that the endocannabinoid system present in every human works in our bodies to maintain balance, or, in another words, homeostasis. They found three important ways cannabis affects differently men and women:

  • Sex differences are fundamental to cannabinoid-regulated biology
  • Males are more sensitive to the appetite-stimulating (munchies) properties of cannabinoids
  • Sex steroid hormones have divergent roles in determining cannabinoid sensitivity

Women seek other things in cannabis

As you can see, women, biologically or physically, experience cannabis in a very different way than men. Females experience more intense effects than male because of the interaction between estrogen, CB1 receptors and cannabinoids, specially THC. But there’s even anthropological and sociological differences, too.

According to a BDS Analytics report, women are more likely to use products like topicals and spend 35% less on cannabis products than men. According to Jessica Lukas, VP Consumer Insights at BDS, women seek different things than men when it comes to cannabis:

“There are some differences in the way females think and behave. We do see females a bit more likely to consume because of anxiety and physical ailments.”

There is so much more fields to investigate and research about how gender can affect the cannabis experience. Maybe next time you use cannabis with friends, both male and female, you can analyze what is different and what is similar in terms of behavior or physical responses. Perhaps you can find some of the things you read here to be true among your friends. But please, do us a favor a don’t be weird about it.


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