CBD Dosage? Less is More… Here’s where to Start

Everyone reacts differently to cannabis. If you are thinking of cannabis for medicinal purposes, it’s very important that you find the exact and right dosage for you.

Take a minute to remember what you feel after one drink. You feel more relaxed, you start talking a little more and feel chipper. But after you had six or more, you start to feel dizzy. And if you push it a little further, you’ll probably make a visit to the toilet and pass out. This is something called the biphasic effect. And, besides alcohol and other substances, cannabis also produces biphasic effects. We’ll explain how the biphasic effect works and how to properly manage dosage to experience the best results.


What is the biphasic effect?

The biphasic effect means that too low or too high doses of cannabis can produce equally negative effects, or worsen your symptoms. And, most importantly, in cannabis, specially when it comes to THC, moderate, balanced doses can make you feel the desired effects. However, high doses can amplify the symptoms you’re trying to get rid of. For example, consuming too much THC can induce anxiety and even a panic attack.

But the biphasic effect doesn’t work the same for everyone. Let’s say you try a CBD cream to manage your back pain. You try it and it works so well that you tell all your friends and family about it. Your aunt is having back pain as well, so you give her some of that cream. But, unfortunately, it doesn’t work for her. Why? Because of the biphasic effect. Maybe your aunt needs a cream with a higher CBD percentage.

Every person is different and has different reactions to substances like cannabis. This is why dosage is so important. And not just any dosage, but the right one for you. And to find the right one you need to understand that cannabis strains have different ratios.

Different strains, different ratios

Even though the market is full with predominant THC strains, CBD has become more popular. According to Google Trends, CBD searches triple THC searches (see table below).

Among the CBD searches, the most popular related topic is “CBD Oil”. The increasing interest in CBD and it’s different products in the market means that people’s interests and curiosity are mainly directed towards the non psychoactive effects of cannabis. To understand it better we need to explore the different strains and categories of products available in the market.

High THC, Low CBD

This type has between 10% and 30% of THC and very little amounts of CBD. Research has found that CBD can even lower or neutralize some of the psychoactive effects of THC. These type of strains will definitely get you high.

But, when it comes to medicinal purposes, a higher dose doesn’t necessarily mean a better effect. With large amounts of THC, the effect is sedating, more than stimulating.

Balanced CBD/THC

This type has a balanced 5% to 15% of THC and CBD. Even though there is no “right dose” for everyone, some think this balanced type is a good starting point. Guillermo Velasco of Complutense University of Madrid is one of the leading scientists researching cannabinoids for cancer treatment. He states that THC has as much medicinal purposes as CBD. “In my opinion as a scientist, I’ve been working with [cannabis] for quite a long time. THC is the compound that has the most potent anti-cancer activity. CBD is helping—we tried a lot of combinations of THC and CBD because it’s good for avoiding the side effects of the therapy […] but, definitely THC is important”.

A 1:1 ratio of CBD and THC is considered to have a very good response to some treatments. Both cannabinoids have the same medicinal benefits such as analgesic and anti-inflammatory effects. So if you want the best result for pain and inflammatory problems, balanced CBD/THC this is your type of product. CBD can cancel the psychoactive effect of THC, so you will experience the medical benefits of THC, but without experiencing so much the psychoactive effects.

High CBD, Low THC

Finally, we have the CBD predominant strains. Products of this type have between 5% and 20% CBD, and under 5% of THC. People who consume these products are sensitive to the side effects of THC. Also, people who need to be in constant medication throughout the day prefer these high CBD concentration products.

But high concentrated CBD products doesn’t necessarily mean more effective. If you have a lot of pain and you are considering CBD, don’t think high doses of this cannabinoid are going to help you even more. According to Project CBD, just 2.5mg of CBD combined with a small amount of THC can have a great medical effect, opposite to high doses of CBD.

In cannabis Dosage, less is more

Above all, cannabis is considered to work better in low doses. For example, let’s take a look at two of the FDA approved medications: Sativex and Epidiolex.

Sativex is a cannabis sublingual spray developed by GW Pharmaceutical. Each spray of 100ml and it contains 2.7mg of THC and 2.5mg of CBD. This means is almost a 1:1 ratio. A study conducted on cancer patients with Sativex prove the concept of “less is more”. Patients who received 21mg a day showed significantly more decrease in pain than those patients who received 52mg a day. Other patients who received 83mg showed no response at all.

Likewise, Epidiolex is another pharmaceutical drug approved by FDA. The drug is indicated for seizures associated with Lennox-Gastaut syndrome or Dravet syndrome in patients 2 years of age and more. Studies prove that just 1mg/kg of body weight, for epileptic children shows better results. What doctors recommend is to start with this small those and slowly increase after watching the patient’s response.

Start low, grow slow

In conclusion, find the right dose for you. But remember this: start low, grow slow. Everyone’s is different, and taking into account the biphasic effect, you and your aunt will experience different effects while using the same CBD cream. It’s better to try products with a low dose of CBD and/or THC and watch your reaction throughout one week. If you don’t experience any changes, increase the dose. But do it in a very small proportion, and watch your reactions again. Try this until you find the right dose for you. And always remember that, in cannabis, a higher dose doesn’t mean better results.


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10 Things You Must Know about CBD

Cannabis has at least 113 different cannabinoids – but the only one on the tip of everyone’s tongue is CBD. This beneficial compound can be derived from hemp and made into an oil. With the development of CBD oil, many people started to discover its amazing mental and physical health benefits. To this day, organic CBD oil continues to amaze those who are using it – or paying attention to the all the newly discovered benefits. You can decide if CBD pure oil from hemp is right for you by learning the 10 following facts about this awesome compound:


1. CBD is a Non-Psychoactive Cannabis Compound

CBD oil comes from the leaves and stalks of the cannabis plant. The type of plant used is usually hemp, as it is not as strictly regulated as marijuana. Despite its origins, CBD does not have any of the psychoactive properties found in THC. Instead, this compound promotes calm, relaxed feelings without the high. When ingested, the CBD compounds bind to the receptors that control the chemicals in the brain. Its impact on brain activity helps CBD control your mental and physical health symptoms

2.  Studies Have Proven the Pain Management Benefits of CBD Oil

Through many different studies, scientific research has shown us how well organic CBD oil controls pain. The positive results from these studies have pushed the FDA to approve CBD treatments for certain health conditions. CBD medications are used to control pain caused by serious health conditions. These conditions include multiple sclerosis, rheumatoid arthritis and cancer. Organic CBD oil can provide the same benefits without all the extra processing.

3.  CBD Oil Can Help Manage Mental Health Conditions

Researchers have found that CBD can help deal with mental health conditions, such as anxiety and depression.  With a small dose of CBD, participants with social anxiety were much less anxious than normal during public speaking. With CBD, depression symptoms decrease as well. This is especially true for the physical ways anxiety and depression manifest. Symptoms like sleeping difficulties and nausea are reduced or eliminated with a single dose of pure CBD oil.

4.  CBD Oil Helps Prevent Relapse

CBD oil promises to change the addiction recovery field by reducing the risk of drug and alcohol relapse. In a recent study, participants only received one dose of CBD every day for a week. Despite the low dose and short duration, they were able to resist relapse for five full months afterward. A reduction in addict-like characteristics were virtually eliminated as well. The lasting effects of organic CBD oil helped these people stop having strong cravings for drugs and alcohol. As a result, they were able to better focus on recovery.

5.  Negative Side Effects of CBD Oil are Minimal

As with any substance you put in your body, CBD pure oil does have minimal side effects to consider. Although they are minor, common CBD side effects include dry mouth, dizziness and drowsiness. You will need to weigh the pros and cons to determine if the benefits of CBD oil outweigh the risks. Pregnant and breastfeeding women should never consume CBD oil. The substance has the chance of passing through the mother’s body to the child.

6.  CBD Oil is Not Likely to Cause a Positive Drug Test

Modern drug tests are only looking for substances that have mind-altering effects. When it comes to cannabis, drug tests are only looking for THC, not CBD. Organic CBD oil from hemp only contains a max of 0.3 percent THC, which is likely undetectable on these tests. While taking organic CBD oil, you likely do not need to worry about failing any drug tests.

7.  You Cannot Actually Get High from CBD Oil

Although it is a compound of cannabis, CBD cannot get you high. Unlike THC, CBD does not cause a high that can disrupt your thought patterns. Instead, the CBD pure oil helps the body by controlling pain, relieving nausea and more.  When taking the right dose of organic CBD oil, you will never feel high or any other mental impairments that could derail your day.

8.  There are No Addictive Properties in CBD Oil

CBD oil does not have any addictive properties to consider. This substance has been cleared of causing addiction by a World Health Organization study. As a result, there is little to no risk of creating dependence or abuse, even after ingesting CBD daily for a long period of time. CBD does not cause cravings nor withdrawal symptoms, if stopped.

9.  CBD Oil Has Nothing to Do with Weed

Although they both come from the cannabis family of plants, marijuana and hemp have very little in common. As a result, pure CBD oil does not have anything to do with marijuana. Instead, organic CBD oil comes from the hemp plant to harness the power of this substance without loading up on the THC content. Weed and CBD remain worlds apart when using hemp for the extraction process.

10. Organic CBD Oil from Hemp Provides the Best Results

When organic CBD oil is derived from the hemp plant, it offers the greatest benefits and poses a minimal risk of side effects. The organic oil goes through the extraction process to isolate the CBD, which helps to purify the oil mixture. The lack of THC in CBD pure oil keeps this substance legal to own and consume in many, but not all, areas. New laws on the books promise to put the federal legalization of hemp products, including CBD oil, at the forefront of everyone’s minds.

Buy CBD Pure Oil Today to Start Your Journey Toward Complete Wellness

Organic CBD oil offers therapeutic benefits for mental and physical health conditions without causing you to feel high or out of it. Make sure you always have CBD oil in your medicine cabinet by acquiring some from your favorite online retailer. Whether you suffer a bout of anxiety or a spike in your pain levels, organic CBD oil from hemp can give you the support you need to get through it all.



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Painkillers vs CBD. What is the best alternative for pain relief?

Pain is something most people deal with from time to time. But if chronic pain keeps you from living a healthy, happy life, you’ll want to get relief.

While it’s easy to swallow a pill to get pain relief, it may not be the best option for long-term use. Read on to learn how pain killer drugs work and why many people are turning to CBD oil for pain.


Types of Painkiller Drugs

Painkillers, also called analgesics, are classified into several different categories. There are two main types of painkiller drugs you can buy without a doctor’s prescription. These include acetaminophen, commonly known as Tylenol, and non-steroidal anti-inflammatory drugs (NSAIDs). Aspirin, ibuprofen (Advil and Motrin) and naproxen sodium (Aleve) are examples of NSAIDs.

Opioids are much stronger pain relievers that your doctor must prescribe for you. You’ll pick up the medicine at a pharmacy and will need to have it refilled by the pharmacist when you run out. Common opioid medications include hydrocodone, hydromorphone, morphine, oxycodone and methadone. Brand names include Vicodin, Percocet, OxyContin, Dilaudid, and others.

How do Painkiller Drugs Work?

Pain relievers work with your body’s nervous system to stop your brain from generating the feeling of pain. You have millions of nerve endings in your skin and tissues. Nerves allow your body to communicate with your brain. When you are injured, these nerves tells your brain where the pain is located in your body and what it feels like.

Painkiller drugs keep the nerves from telling your brain about the pain. Opioids and non-prescription drugs work similarly, but opioids also trigger the pleasure centers of your brain. That’s why these drugs are only used to treat severe pain.

Long-Term Side Effects

While painkiller drugs are an effective way to stop pain, they do come with side effects. For example, NSAIDs can be extremely hard on your stomach and kidneys. Some also cause heart damage. Prolonged use of these drugs can lead to ulcers, bleeding in your gut, or kidney failure.  Tylenol can cause liver damage, especially when taken in high doses or mixed with alcohol.

Opioids are also quite dangerous to take for chronic pain relief. At low doses, opioids can make you feel sleepy or dizzy. At higher doses, they can slow your heart rate and breathing rate, leading to death. Since these drugs not only kill pain but also boost feelings of pleasure, many people become addicted to them. When people are addicted, they take the drug in higher doses, often leading to overdose and death. In 2017, 72,000 people in the United States died from drug overdose.

CBD Oil for Pain Relief

To avoid the dangerous side effects that come with traditional painkillers, many people are using CBD oil for pain management. Extracted from marijuana or hemp plants, the oil contains only trace amounts of THC, the component that makes people feel “high.” Additionally, non-toxic CBD oil does not affect the same brain receptors as THC.

Your body regulates a variety of bodily functions including:

  • Appetite
  • Sleep
  • Pain and Immune system response

Taking CBD oil helps your body regulate these functions naturally.  Pure CBD oil helps reduce pain, inflammation and anxiety, while improving sleep and appetite.

In fact, multiple studies have confirmed the effects of cannabis-based medicine for pain relief. A NCBI study at the Royal Hospital for Rheumatic Diseases in the United Kingdom found “a significant analgesic effect was observed and disease activity was significantly suppressed following…treatment.” The study used a cannabis-based medication to treat patients with rheumatoid arthritis. Another study of patients with migraine headaches points to the active ingredients in CBD oil as a way to treat these debilitating headaches.


CBD Side Effects

Along with treating pain naturally, CBD oil doesn’t come with any of the side effects of prescription or over-the-counter painkillers. Unlike NSAIDS and acetaminophen, CBD oil will not damage your other systems. And, unlike opioids, there’s no chance of becoming addicted. So if you’re looking for a safe, effective way to relieve pain, CBD is a good option.

You don’t need a prescription to buy pure CBD oil, and it’s easy to buy hemp-based CBD online, regardless of where you live. Visit our website to learn more about the benefits of pure organic hemp oil and browse our catalog of products to find the best CBD oil for pain.


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Why is CBD Used for Medicinal Purposes?

Cannabinoids, like CBD, are chemical compounds derived from certain plants in the Cannabaceae family. CBD products have been used for medicinal purposes since ancient times because they help alleviate pain and can treat a variety of ailments.

Historic records exist of its use in China, Scandinavia, Egypt, Greece, and India. By medieval times, CBD had found its way into medical practices in Islamic countries in the Middle East, and it was introduced to modern Western medicine in the United States in the 19th century.


With more and more states legalizing cannabis compounds and even selling them in retail outlets as well as designated dispensaries, the use of medicinal CBD has been growing significantly in recent years. However, many consumers still remain confused concerning various CBD products, particularly when it comes to how they differ from one another, how they are the same, and which types work best for specific ailments and conditions. After all, during the 20th century, governments all over the world did their best to limit the availability of any real, scientific knowledge of the medicinal benefits of cannabis derivatives to the general public.

It should be kept in mind that although cannabis therapy is believed by many in the scientific community to be highly effective, most studies are still in their beginning stage and have not provided definitive answers.

What is THC, and how do THC and CBD differ from one another?

One of the major misconceptions shared by many modern consumers is that the use of these products always induces a “high.” However, this is far from the truth. The compound in cannabis that causes an altered perception is known as Tetrahydrocannabinol (THC). Although THC and CBD share substantial chemical similarities and they both interact with the cannabinoid receptors in the human body, they have one significant difference: THC binds with cannabinoid receptors (CB1) in the brain, while its cousin, CBD, binds with different cannabinoid receptors (CB2), which are mostly located in the periphery of the body, not being significantly present in the brain. Furthermore, when the two compounds are used together, CBD plays a moderating role on the psychoactive effect that THC has.

How they’re the same

Apart from the psychoactive properties, however, CBD and THC share many of the same benefits when it comes to medicinal uses.

Cannabinoids first gained popularity in the 20th century as an alternative to harsh anti-nausea medications. It has been used to combat nausea in cancer patients undergoing chemotherapy for decades. As an added benefit, they were found to stimulate the often lackluster appetites of those diagnosed with cancer.

THC and CBD products are also used to treat chronic or temporary pain, glaucoma, migraine headaches, some forms of arthritis, seizures caused by epilepsy, and muscle spasms associated with multiple sclerosis. They were also used to help mitigate anorexic behavior, and evidence suggests that CBD successfully treats some of the symptoms of AIDS.

Many people struggle with whether to use CBD, THC, or some customized combination of the two compounds. Naturally, the optimal ratio is for each patient is going to depend highly on individual needs and preferences.

What is Isolate CBD Oil?

Most CBD derivatives we come across, from oils to capsules to creams, say Full Spectrum on the bottle. But, every once in a while, particularly when it comes to oils, we come across one that says Isolate CBD Oil. What does it mean? What’s the difference? You must be wondering…

When a product says Isolate CBD, this means that the CBD component in cannabis oil has been specifically isolated from other cannabinoids and components in the plant in order to obtain an almost 100% CBD oil supplement.

Though full spectrum supplements have their own benefits due to the entourage effect, some people are seeking relief of very specific symptoms and require CBD exclusively. For them, Isolate is the way to go.

Some benefits that Isolate CBD Oil provides are:

  • Muscle and Joint pain relief
  • Reduces inflammation
  • Is a powerful antioxidant

Dosage Tips

Dosage is very important when it comes to CBD Isolate or Full Spectrum. Here are some tips that might be useful and informative:

Trial and Error

The most important thing to remember when beginning a journey with medicinal cannabis products is that there’s no real cut-and-dried dosing formula.

Because CBD oil and other CBD-rich products don’t produce a psychoactive effect, it’s recommended that fledgling users begin with a product that contains a minimal amount of THC oil and adjust it upwards over a period of time until the right combination is found. It’s also important to keep in mind that optimal dosage will possibly fluctuate over time with changes in the severity of symptoms and individual tolerance levels.

Does THC and CBD content vary depending on the strain?

Yes, it does! Though every plant can be a little different some strains are THC dominant, others CBD dominant, and others are balanced.

  • THC dominant strains contain higher levels of THC than CBD and, as a consequence, it has strong psychoactive effects.
  • Balanced strains contain a more-or-less equal mixture of both CBD and THC.
  • CBD dominant strains contain higher amounts of CBD than THC.

Less is more

Most people believe that the key to receiving optimal benefits from using medicinal cannabis products lies in high dosages. However, cannabis fails to act like many traditional medications in his respect — higher dosages frequently result in diminished effectiveness. Regardless of what the ailment or condition is, correct dosages is the most important factor when managing symptoms. Fortunately, there are tools available to help users take the guesswork out of figuring out customized dosages. Dr. Sulak’s Six-Day Sensitization Protocol provides a workshop designed to act as a clear navigational tool for those seeking their optimal dosage as well as their ideal THC vs CBD ratio.

What products are available?

Several options exist for those seeking to include cannabinol products in their health and wellness routine. As was previously mentioned, CBD supplements can come as Full Spectrum or as Isolate, but there are several options.

For instance, those with arthritis may find relief by using a CBD cream, while those experiencing muscle pain may decide to opt for a massage oil containing CBD hemp oil. It’s also available in edible form such as gummies or other types of candy. Consumers also have the option of picking indigestible oils in capsules or droppers. Some people prefer to mix it with their favorite beverage, and oral sprays are also available.

Fortunately, there is a wide variety of CBD products available that will work for most people — finding the right fit just involves a little experimentation on the part of the user. Many people enjoy mixing it up a bit when it comes to their CBD products — having a luxurious massage performed with a rich CBD oil, for instance, followed by a drop or two under the tongue to ensure a good night’s sleep.


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How CBD and brown fat could be the key to prevent obesity

Disturbing and troubling data came to surface last year. According to the Center for Disease Control and Prevention, the prevalence of obesity is 39.8% and affects about 93.3 million adults in the United States. Adult obesity rates exceed 35% in states like West Virginia, Mississippi, Iowa, Oklahoma and Alabama.

Even more disturbing are the statistics in children and adolescents. About 18% of people aged between 2 and 19 are obese. To go even deeper, 14.5% of babies between two and four years old suffer from obesity. As you can see, this is a nationwide problem.


What worries the medical community is that obesity is one of the principal risk factors for diabetes and other serious conditions. The National Diabetes Statistics Report stated that on 2017, more than 23 million people in the United States suffer from diabetes. The report doesn’t discriminate between type 1 or type 2 diabetes. However, it clarifies that “type 2 diabetes accounts for 90% to 95% of all diabetes cases”. And type 2 diabetes can be easily avoided. How? Reducing body weight is a perfect starting point.

Even though body fat is associated with excess weight and obesity, that is not entirely accurate. Research over the past years suggests that brown fat in our bodies could actually help us lose weight. And scientist’s curiosity has gone even further, so studies are now linking CBD to brown fat, which means that CBD can actually be involved in preventing obesity, and as a direct consequence, diabetes.

Endocannabinoid system, CBD and metabolism

All vertebrate animals have an endocannabinoid system (ECS). The ECS plays a key role in homeostasis, which helps the body keep everything in balance. When cannabinoids interact with the ECS, it can regulate appetite, pain, inflammation, thermoregulation, muscle control, energy balance and stress, among others.

The ECS also plays an important role in metabolism. It helps regulate calories before turning them into energy, as well as fat metabolism. This link between metabolism, fat burning and cannabinoids caused scientists to start thinking: Is there any correlation between the endocannabinoid system, CBD and weight loss? Brown fat was the missing piece of the puzzle.

Understanding body fats

Although body fat has a negative connotation, not all fats are bad. The mayor role of fats is to store and use energy for our body. Without fat, the body won’t be able to store and use energy when it’s needed. But, too much fat is not good for your body, mainly because it can lead to obesity and related conditions. It is important to differentiate two types of fats: white fat and brown fat, in order to understand how CBD can prevent obesity.

White Fat

White fat, also known as white adipose tissue (WAT), is our body’s main type of fat. It is found under the skin and also around internal organs. This last type of fat is known as visceral fat. White fat is our main source of energy. It stores energy and accumulates it in our bodies. When this type of fat accumulates, it produces energy and keeps the body warm. White fat also works as a sensor for hormones such as insulin and other hormones that are related to sex and stress.

But too much white fat can be harmful. If you consume more calories than you can burn, this will produce accumulation of white fat. If accumulated in excess, white fat can lead to obesity and create a higher risk of diabetes, high blood pressure, and heart disease.

White fat is not the only fat that interacts with our bodies. There is another type of fat that can help get rid of that accumulated white fat.

Brown Fat

Brown fat, or brown adipose tissue (BAT) also stores energy, but in a much smaller space than white fat does. It is called brown fat because of its color. It contains iron rich mitochondria, and because of this it gets its brownish color. And the main purpose of this fat is to burn.

Brown fat uses the energy from calories to burn and then create heat. This process is called thermogenesis. When brown fat starts burning, it also burns calories. So, in the process of keeping us warm, brown fat can also help us lose and/or maintain a healthy weight. Brown fat is found mainly in animals. Before hibernation, animals increase their body fat by eating more than usual in the months prior to winter. When they enter hibernation, brown fat starts doing all the burning, keeping them cozy and warm. Babies also accumulate large amounts of brown fat to keep their bodies warm. Adults have brown fat too, but in a much smaller scale. It is mostly reserved in the neck and shoulders.

How to increase brown fat levels

There are several ways to increase brown fat. Exercising on a regular basis and sleeping in cooler temperatures makes the body produce more brown fat to keep warm. Also, eating food high on melatonin, such as ginger and cherries, can increase brown fat.

But white fat is very easy to acquire and accumulate, unlike brown fat. If there is a way to transform white fat into brown fat, this could be a breakthrough in the fight against obesity. Well, a recent study suggests that CBD has the ability to do just that.

CBD can transform white fat into brown fat, study suggests

On April 2016, Korean scientists published a research paper which is the first step towards understanding how CBD is able to play a major role in preventing obesity. Hilal Ahmad Parray and Jong Won Yun set to study the effects of CBD and its potential as a treatment and prevention of obesity. The paper was published in the scientific journal Molecular and Cellular Biochemistry. Their findings were remarkable.

They found that CBD can stimulate genes and proteins that will eventually improve the processes of breaking down and oxidizing fat. It will also increase the body’s ability to burn calories by expanding the activity of mitochondria. Remember that mitochondria are what makes brown fat look that way.

Hilal Ahmad Parray and Jong Won Yun also discovered that CBD can “decrease the expression of proteins involved in fat cell generation.

When they analysed all of this results together, they realized CBD has the ability to induce a process they call “fat browning”. This means that CBD can transform white fat in our bodies into brown fat. And we already explained how brown fat, by burning calories, can help us lose weight. This is what the Korean researchers concluded:

“These data suggest possible roles for CBD in browning of white adipocytes, augmentation of lipolysis, thermogenesis, and reduction of lipogenesis. In conclusion, the current data suggest that CBD plays dual modulatory roles in the form of inducing the brown-like phenotype as well as promoting lipid metabolism. Thus, CBD may be explored as a potentially promising therapeutic agent for the prevention of obesity”.

CBD and prevention of diabetes

CBD has potential benefits for people who suffer from diabetes. When these cannabinoids interacts with the endocannabinoid system, they have the ability to stabilize blood sugars. Also, it can reduce neuropathic pain by working as an anti inflammatory agent of nerves. This anti inflammatory property also helps in arterial inflammation, which is very common in diabetes. Cannabidiol also serves as antispasmodic agent that will relieve cramps and gastrointestinal disorders. However, there is no clinical evidence.

But, even if there is a lack of clinical studies (in humans) to support this hypothesis, preclinical studies conducted on mice are the ground point for further research to prove how CBD can prevent type 2 diabetes in humans.

In 2006, Israeli researchers from the Hadassah University Hospital in Jerusalem published a study to investigate how CBD can lower incidence of diabetes in mice. They reported that mice significantly reduced the incidence of diabetes: from an  incidence of 86% in non-treated control mice to an incidence of 30% in CBD-treated mice. After closely examining pancreatic islets, they also concluded that CBD-treated mice revealed significantly reduced insulitis.

What is more promising is the fact that a clinical trial is about to come to surface. Also in Israel, researchers from Ananda Scientific Mission Statement are in the process of arrangements for Phase 2 trials on CBD and diabetes.

Chief Executive Officer Mark J. Rosenfeld stated the potential benefits of CBD in treating diabetes: “Unlike insulin and other existing medications for diabetes, CBD may actually suppress, reverse and perhaps cure the disease. So, the therapeutic alternatives offered by cannabis chemistry could go far in helping resolve conditions responsible for a huge public health crisis in China and elsewhere.”

Evidence shows promise, but clinical trials are needed

As obesity tendency in the United States grows every year, it has become a public health matter. Even more when obesity increases the the risk of type 2 diabetes. It is believed in the medical community that brown fat can induce weight loss by burning calories in the process of thermogenesis. Research has gone further and set a correlation between CBD and how this cannabinoid has a “browning fat effect”, which can transform white fat into brown fat. Other studies on mice suggests that CBD can also prevent diabetes.

CBD shows promise on preventing type 2 diabetes and obesity. However, studies suggest that further research is needed to understand and analyze how CBD can prevent this two conditions in humans.


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